Anti-HDAC6 (3B2) Mouse antibody

Cat.#: 168403

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Product Information

  • Product Name
    Anti-HDAC6 (3B2) Mouse antibody
  • Documents
  • Description
    HDAC6 (3B2) Mouse monoclonal antibody
  • Tested applications
    WB
  • Species reactivity
    Human
  • Alternative names
    FLJ16239 ;HD 6 ;HD6 ;HDAC 6 ;HDAC6 ;HDAC6_HUMAN ;Histone deacetylase 6 (HD6) ;Histone deacetylase 6 ;JM 21 ;JM21 ;KIAA0901 ;OTTHUMP00000032398 ;OTTHUMP00000197663 antibody
  • Isotype
    Mouse IgG2a
  • Preparation
    Antigen: Purified recombinant human HDAC6 protein expressed in E.coli.
  • Clonality
    Monoclonal
  • Formulation
    Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

  • Validations

    Western blot detection of HDAC6 in T47D,Jurkat CHO-K1(B) and CHO-K1 transfected by HDAC6-fragment EGFP fusion proteinuff08Auff09cell lysates using HDAC6 mouse mAb (1:1000 diluted).

    Western blot detection of HDAC6 in T47D,Jurkat CHO-K1(B) and CHO-K1 transfected by HDAC6-fragment EGFP fusion proteinuff08Auff09cell lysates using HDAC6 mouse mAb (1:1000 diluted).

  • Background
    Swiss-Prot Acc.Q9UBN7.Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"