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Anti-HDAC3 (3G3) Mouse antibody

Cat.#: 168208

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Product Information

  • Product Name
    Anti-HDAC3 (3G3) Mouse antibody
  • Documents
  • Description
    HDAC3 (3G3) Mouse monoclonal antibody
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    HD 3;HD3;HDAC 3;HDAC3;HDAC3_HUMAN;Histone deacetylase 3 (HD3) (RPD3-2);histone deacetylase 3;RPD 3;RPD3 2;RPD3;RPD3-2;SMAP 45;SMAP45. antibody
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Purified recombinant human HDAC3 protein fragments expressed in E.coli.
  • Clonality
    Monoclonal
  • Formulation
    PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/1000

  • Validations

    Western blot detection of HDAC3 in THP-1,LNCAP,MCF7,PC12,293,Jurkat,3T3 and Hela cell lysates using HDAC3 mouse mAb (1:1000 diluted).Predicted band size:49KDa.Observed band size:49KDa.

    Western blot detection of HDAC3 in THP-1,LNCAP,MCF7,PC12,293,Jurkat,3T3 and Hela cell lysates using HDAC3 mouse mAb (1:1000 diluted).Predicted band size:49KDa.Observed band size:49KDa.

    Western blot analysis of extracts from HDAC3 knock dowm 293T, wild-type (WT), K562, Jurkat and Hela cell lysates using HDAC3 Mouse mAb (upper,1:500 diluted) or Beta Actin (200068-8F10) Mouse mAb (lower,1:10000 diluted).Predicted band size:49KDa.Observed band size:49KDa.

    Western blot analysis of extracts from HDAC3 knock dowm 293T, wild-type (WT), K562, Jurkat and Hela cell lysates using HDAC3 Mouse mAb (upper,1:500 diluted) or Beta Actin (200068-8F10) Mouse mAb (lower,1:10000 diluted).Predicted band size:49KDa.Observed band size:49KDa.

    Western blot detection of HDAC3 in Jurkat and Hela cell lysates using HDAC3 mouse mAb (1:1000 diluted).Predicted band size:49KDa.Observed band size:49KDa.

    Western blot detection of HDAC3 in Jurkat and Hela cell lysates using HDAC3 mouse mAb (1:1000 diluted).Predicted band size:49KDa.Observed band size:49KDa.

  • Background
    Swiss-Prot Acc.O15379.Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation By similarity.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"