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Product Name
Anti-GSTZ1 antibody
- Documents
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Description
Rabbit polyclonal to GSTZ1
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Tested applications
ELISA, WB, IHC-P, IP
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Species reactivity
Human GSTZ1
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Alternative names
glutathione S-alkyltransferase antibody; glutathione S-aralkyltransferase antibody; glutathione S-aryltransferase antibody; glutathione S-transferase zeta 1 antibody; glutathione S-transferase zeta 1 antibody; glutathione transferase zeta 1 antibody; glutathione transferase zeta 1 (maleylacetoacetate isomerase) antibody; GSTZ1 antibody; Gstz1 antibody; GSTZ1-1 antibody; GSTZ1-1 antibody; MAAI antibody; MAAI antibody; MAI antibody; maleylacetoacetate isomerase antibody; maleylacetoacetate isomerase antibody; maleylacetone isomerase antibody; S-(hydroxyalkyl)glutathione lyase antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human GSTZ1 (rh GSTZ1; NP_665877.1; Met1-Ala216). GSTZ1 specific IgG was purified by Human GSTZ1 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 5-10 μg/ml
ELISA:0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human GSTZ1. The detection limit for Human GSTZ1 is 0.00245 ng/well.
IHC-P: 0.1-2 μg/ml
IP: 1-4 μg/mg of lysate
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Validations
GSTZ1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
GSTZ1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
GSTZ1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
GSTZ1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
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Background
GSTZ1 gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. GSTZ1 is a bifunctional protein which has minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. GSTZ1 catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. GSTZ1 participates in the catabolism of phenylalanine and tyrosine. Thus defects in GSTZ1 cause harsh metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia.
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References
- Tong Z. et al., 1999, Chem Res Toxicol. 11 (11): 1332-8.
- Tong Z. et al., 1999, Biochem J. 331 (2): 371-4.
- Ketterer B. 2001, Chem Biol Interact. 138 (1): 27-42.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"