Anti-Glypican 3/GPC3/OCI-5 antibody

Anti-Glypican 3/GPC3/OCI-5 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to Glypican 3/GPC3/OCI-5

WB, IP

Human Glypican 3 / GPC3 / OCI-5

AC002420.1 antibody; DGSX antibody; Glypican 3 antibody; Glypican 3 antibody; GPC3 antibody; GPC3 antibody; GTR2-2 antibody; MXR7 antibody; OCI-5 antibody; OCI-5 antibody; RP23-33P21.1 antibody; SDYS antibody; SGB antibody; SGBS antibody; SGBS1 antibody; SGB antibody; DGSX antibody; MXR7 antibody; SDYS antibody; SGBS antibody; OCI-5 antibody; SGBS1 antibody; GTR2-2 antibody; OCI-5 antibody

Rabbit IgG

Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human Glypican 3 / GPC3 / OCI-5, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in lung, liver, and kidney. It is a heparan sulfate proteoglycan, which is overexpressed in various neoplasms such as hepatocellular carcinoma, malignant melanoma, and testicular yolk sac tumor, and plays an important role in cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 acts as a tumor suppressor gene, whereas in others, it acts as an oncofetal protein. Studies have shown that GPC3 is a reliable marker for hepatocellular carcinoma. The sensitivity and specificity exceeds both alpha-fetoprotein and hepatocyte-paraffin1. GPC3 immunohistochemistry can aid in the differentiation of testicular germ cell tumors, being expressed in all yolk sac tumors but not in seminomas. GPC3 expression has also been identified in some squamous cell carcinomas of the lung and clear cell carcinomas of the ovary. The role of GPC3 in melanomas is still controversial. Thus, Glypican-3 is currently regarded as a tumor marker and potential target for immunotherapy.

• Kandil DH, et al. (2009) Glypican-3: a novel diagnostic marker for hepatocellular carcinoma and more. Adv Anat Pathol. 16(2): 125-9.
• Maeda D, et al. (2009) Glypican-3 expression in clear cell adenocarcinoma of the ovary. Mod Pathol. 22(6): 824-32.