Anti-GLO1/Glyoxalase 1 antibody

Anti-GLO1/Glyoxalase 1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to GLO1/Glyoxalase 1

ELISA, WB, IP

Mouse Glyoxalase I / GLO1

GLYI antibody; GLOD1 antibody; HEL-S-74 antibody; GLY1 antibody; Qglo antibody; Glo-1 antibody; Glo-1r antibody; Glo-1s antibody; Glo1-r antibody; Glo1-s antibody; AW550643 antibody; 0610009E22Rik antibody; 1110008E19Rik antibody; 2510049H23Rik antibody; Glyoxalase I antibody; 0610009E22Rik antibody; 1110008E19Rik antibody; 2510049H23Rik antibody; AW550643 antibody; Glo1 antibody; GLO1 antibody; Glo-1 antibody; Glo-1r antibody; Glo1-r antibody; Glo-1s antibody; Glo1-s antibody; GLOD1 antibody; GLY1 antibody; GLYI antibody; Glyoxalase 1 antibody; Glyoxalase 1 antibody; Qglo antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Mouse GLO1 (rM GLO1; NP_079650.3; Ala 2-Ile 184). GLO1 specific IgG was purified by mouse GLO1 affinity chromatography

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Mouse Lactoylglutathione lyase, also known as Methylglyoxalase, Aldoketomutase, Glyoxalase I, Ketone-aldehyde mutase, S-D-lactoylglutathione methylglyoxal lyase and GLO1, is a member of the glyoxalase I family. GLO1 / Glyoxalase I is a ubiquitous cellular defense enzyme involved in the detoxification of methylglyoxal, a cytotoxic byproduct of glycolysis. Accumulative evidence suggests an important role of GLO1 expression in protection against methylglyoxal-dependent protein adduction and cellular damage associated with diabetes, cancer, and chronological aging. GLO1 / Glyoxalase I has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. GLO1 / Glyoxalase I catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. GLO1 / Glyoxalase I exists in three separable isoforms which originate from two alleles in the genome. These correspond to two homodimers and one heterodimer composed of two subunits showing different electrophoretic properties. GLO1 upregulation may play a functional role in glycolytic adaptations of cancer cells.

• Wu, YY. et al., 2008,Prog Neuropsychopharmacol Biol Psychiatry. 32 (7):1740-4.
• Williams,R. et al., 2009, PLoS One  4 (3): e4649.
• Antognelli,C. et al., 2009, BMC Cancer  9 :115.
• Bair,W.B. et al., 2010, Melanoma Res  20 (2):85-96.