Anti-GFAP antibody

Anti-GFAP antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to GFAP

IHC-P

Human GFAP

AI836096 antibody; ALXDRD antibody

Rabbit IgG

Produced in rabbits immunized with purified, a synthetic peptide corresponding to the C-terminus of the Human GFAP, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

GFAP is a cell-specific marker which belongs to the intermediate filament family. It can distinguish astrocytes from other glial cells during development. GFAP is expressed in cells lacking fibronectin. It is a type III intermediate filaments protein which contains three domains: the head, rod and tail domains. GFAP functions in many important entral nervous system (CNS) processes, including cell communication and the functioning of the blood brain barrier. Improper GFAP regulation can cause multiple disorders. Defects in GFAP is related to Alexander disease which is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes.

• Buniatian G, et al., 1998, Biology of the cell. 90(1): 53-61.
• Chen YS, et al., 2011, Experimental Cell Research. 317(16): 2252-66.
• Isaacs A, et al., 1998, Genomics. 51(1): 152-4.