Anti-GFAP antibody

Cat.#: 104428

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Product Information

  • Product Name
    Anti-GFAP antibody
  • Documents
  • Description
    Rabbit polyclonal to GFAP
  • Tested applications
    IHC-P
  • Species reactivity
    Human GFAP
  • Alternative names
    AI836096 antibody; ALXDRD antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, a synthetic peptide corresponding to the C-terminus of the Human GFAP, and purified by antigen affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 0.1-2 μg/mL

  • Validations

    GFAP Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    GFAP Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of human GFAP in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).

    GFAP Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    GFAP Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of human GFAP in human clear cell tumors (brain) with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).

    GFAP Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    GFAP Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of human GFAP in human glioma with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).

  • Background
    GFAP is a cell-specific marker which belongs to the intermediate filament family. It can distinguish astrocytes from other glial cells during development. GFAP is expressed in cells lacking fibronectin. It is a type III intermediate filaments protein which contains three domains: the head, rod and tail domains. GFAP functions in many important entral nervous system (CNS) processes, including cell communication and the functioning of the blood brain barrier. Improper GFAP regulation can cause multiple disorders. Defects in GFAP is related to Alexander disease which is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes.
  • References
    • Buniatian G, et al., 1998, Biology of the cell. 90(1): 53-61.
    • Chen YS, et al., 2011, Experimental Cell Research. 317(16): 2252-66.
    • Isaacs A, et al., 1998, Genomics. 51(1): 152-4.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"