Anti-GAPDH antibody

Cat.#: 104818

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Product Information

  • Product Name
    Anti-GAPDH antibody
  • Documents
  • Description
    Rabbit polyclonal to GAPDH
  • Tested applications
    IHC-P
  • Species reactivity
    Human GAPDH
  • Alternative names
    G3PD antibody; GAPD antibody; HEL-S-162eP antibody; Gapd antibody; CDABP0047 antibody; G3PD antibody; Gapd antibody; GAPD antibody; MGC102544 antibody; MGC102546 antibody; MGC103191 antibody; MGC88685 antibody; MGC103190 antibody; MGC105239 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with A synthetic peptide corresponding to the center region of the human GAPDH, and purified by antigen affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 0.1-2 μg/mL

  • Validations

    GAPDH Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    GAPDH Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of human GAPDH in human hepatitis with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).

    GAPDH Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    GAPDH Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry

    Immunochemical staining of human GAPDH in human renal carcinoma with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections).

  • Background
    Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. A recent report suggests that GAPDH may be genetically associated with late-onset of Alzheimer's disease. Besides, deprenyl, which has originally been used as a monoamine oxidase inhibitor for Parkinson's disease, binds to GAPDH and displays neuroprotective actions.
  • References
    • Hara MR, et al. (2006) Neuroprotection by pharmacologic blockade of the GAPDH death cascade. PNA. 103 (10): 3887-9.
    • Hara MR, et al. (2006) GAPDH as a sensor of NO stress.Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1762 (5): 502-9.
    • Tarze A, et al. (2007) GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilizationGAPDH and apoptosis. Oncogene. 26: 2606-20.
    • Yi MK, et al. (2000) Functional Significance of the Interaction of Hepatitis A Virus RNA with Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH): Opposing Effects of GAPDH and Polypyrimidine Tract Binding Protein on Internal Ribosome Entry Site Function. Journal of Virology. 74 (14) : 6459-68.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"