Anti-G-CSFR/CD114 antibody

Anti-G-CSFR/CD114 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to G-CSFR/CD114

FCM

Human G-CSFR / CD114 / CSF3R

CD114 antibody; Csf3r antibody; CSF3R antibody; Csfgr antibody; GCSFR antibody; G-CSFR antibody; G-CSFR antibody; MGC141472 antibody; MGC141473 antibody; RP23-140F18.1 antibody; CD114 antibody; GCSFR antibody; Cd114 antibody; Csfgr antibody; G-CSFR antibody; G-CSF-R antibody; Cd114 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human G-CSFR / CD114 / CSF3R (rh VE-Cadherin / CD144 / CDH5; CAA56306.1; Met1-Gln593) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.

Monoclonal

Aqueous solution containing 0.5% BSA and 0.09% sodium azide

This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

FCM

Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.

• Kasper B, et al. (1999) Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte colony-stimulating factor receptor (G-CSFR) is not abrogated in neutrophils from severe congenital neutropenia patients with point mutations in the G-CSFR mRNA. Int J Hematol. 70(4): 241-7.
• Hollenstein U, et al. (2000) Endotoxin down-modulates granulocyte colony-stimulating factor receptor (CD114) on human neutrophils. J Infect Dis. 182(1): 343-6.
• Kindwall-Keller TL, et al. (2008) Role of the proteasome in modulating native G-CSFR expression. Cytokine. 43(2): 114-23.
• Beel K, et al. (2009) G-CSF receptor (CSF3R) mutations in X-linked neutropenia evolving to acute myeloid leukemia or myelodysplasia. Haematologica. 94(10): 1449-52.