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Product Name
Anti-FHIT antibody
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Description
Rabbit Polyclonal to Human FHIT
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Tested applications
ELISA, IHC-P, ICC/IF, IF
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Species reactivity
Human Fragile histidine triad / FHIT
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Alternative names
FRA3B antibody; AP3Aase antibody; Fra14A2 antibody; AW045638 antibody; 5'''-P1 antibody; 5'''-P1 antibody; AP3A hydrolase antibody; AP3A hydrolase antibody; AP3Aase antibody; AP3Aase antibody; AW045638 antibody; bis(5'-adenosyl)-triphosphatase antibody; bis(5'-adenosyl)-triphosphatase antibody; diadenosine 5' antibody; diadenosine 5' antibody; diadenosine triphosphate hydrolase antibody; dinucleosidetriphosphatase antibody; dinucleosidetriphosphatase antibody; FHIT antibody; Fhit antibody; Fra14A2 antibody; FRA3B antibody; fragile histidine triad antibody; fragile histidine triad gene antibody; fragile histidine triad protein antibody; P3-triphosphate hydrolase antibody; P3-triphosphate hydrolase antibody; tumor suppressor protein antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human Fragile histidine triad / FHIT . Fragile histidine triad / FHIT specific IgG was purified by Human Fragile histidine triad / FHIT affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human Fragile histidine triad / FHIT.
IHC-P: 0.1-2μg/mL
ICC/IF: 0.5-3μg/mL
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Validations
Human Fragile histidine triad / FHIT Immunohistochemistry(IHC) 15867
Human Fragile histidine triad / FHIT Immunohistochemistry(IHC) 15868
Human Fragile histidine triad / FHIT Immunofluorescence(IF) 15869
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Background
Fragile histidine triad, also known as FHIT, may play a key role in differentiating humans from apes. Fragile histidine triad gene belongs to the histidine triad gene family. It has been shown that fragile histidine triad synergizes with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. Fragile histidine triad gene works as a tumor suppressor as it has been demonstrated in animal studies. The exact molecular function of FHIT is still partially unclear. It also acts as a tumor suppressor of HER2/neu driven breast cancer.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"