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Product Name
Anti-EWSR1 Rabbit antibody
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Description
EWSR1 Rabbit polyclonal antibody
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Tested applications
WB, ICC/IF
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Species reactivity
Human, Mouse, Rat
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Alternative names
EWS; EWS-FLI1; bK984G1.4 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human EWSR1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/2000-1/10000
ICC/IF: 1/50-1/200
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Validations
Western blot detection of EWSR1 in MCF7,3T3,Hela cell lysates using EWSR1 Rabbit pAb(1:1000 diluted).Predicted band size:69KDa.Observed band size:85KDa.
Immunocytochemistry of EWSR1(green) in Hela cells using EWSR1 Rabbit pAb at dilution 1/50, and DAPI(blue)
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Background
Swiss-Prot Acc.Q01844.Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.SitesFeature keyPosition(s)Description
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"