Anti-Endoglin/CD105 antibody

Anti-Endoglin/CD105 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to Endoglin/CD105

WB, IHC-P

Human CD105

AI528660 antibody; AI662476 antibody; CD105 antibody; CD105 antibody; END antibody; Endoglin antibody; Endoglin antibody; Eng antibody; ENG antibody; FLJ41744 antibody; HHT1 antibody; ORW antibody; ORW1 antibody; RP11-228B15.2 antibody; RP23-17P12.4 antibody; S-endoglin antibody; END antibody; HHT1 antibody; ORW1 antibody; Endo antibody; CD105 antibody; AI528660 antibody; AI662476 antibody; S-endoglin antibody

Rabbit IgG

Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human CD105, and purified by antigen affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.