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Product Name
Anti-E2F4 Rabbit antibody
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Description
E2F4 Rabbit monoclonal antibody
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Tested applications
WB, FC
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Species reactivity
Human
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Alternative names
E2F-4 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human E2F4
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
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Validations
Western blot detection of E2F4 in K562 cell lysates using E2F4 Rabbit mAb(1:1000 diluted).Predicted band size:44kDa.Observed band size:65kDa.
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Background
Swiss-Prot Acc.Q16254.Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"