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Product Name
Anti-DYNLL1 Rabbit antibody
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Description
DYNLL1 Rabbit monoclonal antibody
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Tested applications
WB, IHC-P, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human DYNLL1
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Clonality
Monoclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
1:1000-1:5000
1:20
1:200
1:20
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Validations
Western blot detection of DYNLL1 in 3T3,Hela cell lysates using DYNLL1 Rabbit mAb(1:1000 diluted).Predicted band size:10kDa.Observed band size:10kDa.
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Background
Swiss-Prot Acc.P63167.Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"