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Product Name
Anti-DGAT1 Rabbit antibody
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Description
DGAT1 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC, IP
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Species reactivity
Human
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Alternative names
ARAT; DGAT; ARGP1; DIAR7 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human DGAT1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/2000-1/10000
IHC: 1/20
ICC/IF: 1/20
FC: 1/20
IP: 1/20
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Validations
Western blot detection of DGAT1 in K562 cell lysates using DGAT1 Rabbit pAb(1:1000 diluted).Predicted band size:55kDa.Observed band size:55kDa.
Immunohistochemistry of DGAT1 in paraffin-embedded Human colon cancer tissue using DGAT1 Rabbit pAb at dilution 1/20
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Background
Swiss-Prot Acc.O75907.Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"