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Product Name
Anti-DcR2 Rabbit antibody
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Description
DcR2 Rabbit monoclonal antibody
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Tested applications
WB, IHC-P, ICC/IF
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Species reactivity
Human
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Alternative names
DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human DcR2
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Clonality
Monoclonal
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Formulation
50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
IHC: 1/50
ICC/IF: 1/20
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Validations
Western blot detection of DcR2 in Jurkat cell lysates using DcR2 Rabbit mAb(1:500 diluted).Predicted band size:42kDa.Observed band size:35kDa.
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Background
Swiss-Prot Acc.Q9UBN6.Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"