Anti-DC-SIGN/CD209 antibody

Anti-DC-SIGN/CD209 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to DC-SIGN/CD209

ELISA, WB

Human DC-SIGN / CD209

CD209 antibody; CD209 antibody; Cd209a antibody; CDSIGN antibody; CDSIGN antibody; CIRE antibody; CLEC4L antibody; Dcsign antibody; DC-SIGN antibody; DC-SIGN antibody; DC-SIGN1 antibody; DC-SIGN1 antibody; MGC129965 antibody; MGC130443 antibody; SIGN-R1 antibody; SIGNR5 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human DC-SIGN / CD209 (rh DC-SIGN / CD209; NP_066978.1; Lys62-Ala404).

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3) grabbing nonintegrin (DC-SIGN), also known as CD209, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. DC-SIGN also mediates capture and internalization of viral, bacterial, and fungal pathogens by dendritic cells, such as HIV-1, Ebola virus, cytomegalovirus, Dengue virus, and hepatitis C virus. DC-SIGN is unique in that it regulates adhesion processes, such as DC trafficking and T-cell synapse formation, as well as antigen capture. Moreover, even though several C-type lectins have been shown to bind HIV-1, DC-SIGN does not only capture HIV-1 but also protects it in early endosomes allowing HIV-1 transport by DC to lymphoid tissues, where it enhances trans infection of T cells.

• Geijtenbeek TB, et al. (2002) DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukoc Biol. 71(6): 921-31.
• Masso M. (2003) DC-SIGN points the way to a novel mechanism for HIV-1 transmission. MedGenMed. 5(2): 2.
• Zhou T, et al. (2006) DC-SIGN and immunoregulation. Cell Mol Immunol. 3(4): 279-83.