Anti-Cystatin E / CST6 antibody

Anti-Cystatin E / CST6 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse monoclonal to Cystatin E / CST6

IHC-P

Human Cystatin E / CST6

cystatin M antibody; cystatin M/E antibody; 7E11Rik antibody; Cst6 antibody; cystatin 6 antibody; Cystatin E antibody; Cystatin E antibody; ichq antibody; N28197 antibody; CST6 antibody; cysteine proteinase inhibitor antibody; ichq antibody; N28197 antibody; 1110017E11Rik antibody

Mouse IgG1

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cystatin E / CST6 (rh Cystatin E / CST6; NP_001314.1; Met1-Met149). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Cystatin E/M, also referred to as CST6, is a member of type 2 cysteine proteinase inhibitors of the cystatin superfamily, and inhibits papain and cathepsin B. Cystatin E is a low molecular mass secreted protein existing in both a glycosylated (17 kDa) and an unglycosylated (14 kDa) form, with two characteristic intrachain disulfide bridges. Expression of cystatin M/E is found to be restricted to the epidermis, more specifically in the stratum granulosum, sweat glands, sebaceous glands, and the hair follicles. In addition to its function as a cysteine protease inhibitor, cystatin M/E also serves as a target for cross-linking by transglutaminases. Accordingly, cystatin M/E was suggested to be involved in barrier formation and maintenance. Furthermore, studies have revealed that cystatin M/E is frequently epigenetically inactivated during breast carcinogenesis, and thus be regarded as a candidate of tumour suppressor gene.