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Anti-CXCL1 antibody

Cat.#: 104925

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Product Information

  • Product Name
    Anti-CXCL1 antibody
  • Documents
  • Description
    Rabbit polyclonal to CXCL1
  • Tested applications
    WB, IP
  • Species reactivity
    Human CXCL1
  • Alternative names
    KC antibody; MGSA antibody; CXCL1 antibody; CXCL1 antibody; Fsp antibody; FSP antibody; gro antibody; Gro1 antibody; GRO1 antibody; GROa antibody; Mgsa antibody; MGSA-a antibody; N51 antibody; NAP-3 antibody; Scyb1 antibody; SCYB1 antibody; FSP antibody; GRO1 antibody; GROa antibody; MGSA antibody; NAP-3 antibody; SCYB1 antibody; MGSA-a antibody; KC antibody; Fsp antibody; N51 antibody; gro antibody; Gro1 antibody; Mgsa antibody; Scyb1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human CXCL1, and purified by antigen affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 10-20 μg/ml

    IP: 0.5-2 uL/mg of lysate

  • Validations

    CXCL1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    CXCL1 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    CXCL1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation

    CXCL1 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation

  • Background
    The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.
  • References
    • Wang JG, et al. (2008) The chemokine CXCL1/growth related oncogene increases sodium currents and neuronal excitability in small diameter sensory neurons. Mol Pain. 4: 38.
    • Acosta JC, et al. (2009) A role for CXCR2 in senescence, but what about in cancer? Cancer Res. 69(6): 2167-70.
    • Onan D, et al. (2009) The chemokine Cxcl1 is a novel target gene of parathyroid hormone (PTH)/PTH-related protein in committed osteoblasts. Endocrinology. 150(5): 2244-53.
    • Ritzman AM, et al. (2010) The chemokine receptor CXCR2 ligand KC (CXCL1) mediates neutrophil recruitment and is critical for development of experimental Lyme arthritis and carditis. Infect Immun. 78(11): 4593-600.
    • Bolitho C, et al. (2010) The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor receptor. Endocr Relat Cancer. 17(4): 929-40.
    • Wenke AK, et al. (2011) The transcription factor AP-2? regulates CXCL1 during cartilage development and in osteoarthritis. Osteoarthritis Cartilage. 19(2): 206-12.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"