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Product Name
Anti-Cullin 5/CUL-5 Rabbit antibody
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Description
Cullin 5/CUL-5 Rabbit polyclonal antibody
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Tested applications
WB
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Species reactivity
Human, Mouse, Rat
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Alternative names
CUL-5; VACM1; VACM-1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human Cullin 5
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/5000
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Validations
Western blot detection of Cullin 5/CUL-5 in C6,3T3,Hela cell lysates using Cullin 5/CUL-5 Rabbit pAb(1:1000 diluted).Predicted band size:91kDa.Observed band size:91kDa.
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Background
Swiss-Prot Acc.Q93034.Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
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