Anti-CTSZ / CTSX / Cathepsin Z antibody

Anti-CTSZ / CTSX / Cathepsin Z antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to CTSZ / CTSX / Cathepsin Z

ELISA, IHC-P

Human CTSZ / CTSX / Cathepsin Z

AI787083 antibody; AU019819 antibody; Cathepsin X antibody; Cathepsin X antibody; Cathepsin Z antibody; Cathepsin Z antibody; CTSX antibody; CTSX antibody; Ctsz antibody; CTSZ antibody; D2Wsu143e antibody; FLJ17088 antibody; RP23-59M10.3 antibody; CTSX antibody; CTSX antibody; AI787083 antibody; AU019819 antibody; D2Wsu143e antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human CTSZ / CTSX / Cathepsin Z (rh CTSZ / CTSX / Cathepsin Z; Q9UBR2; Met1-Val303). CTSZ / CTSX / Cathepsin Z specific IgG was purified by Human CTSZ / CTSX / Cathepsin Z affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Cathepsin Z (CTSZ), also known as Cathepsin X or CATX, belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ‘mini loop’. Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus, and in contrast to cathepsin B, it does not act as an endopeptidase. It is restricted to the cells of theimmune system, predominantly monocytes, macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues, suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells, a process, which is crucial in the initiation of adaptive immunity. Furthermore, higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa, especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources, suggesting that this enzyme may participate in tumor progression.

• Santamara I, et al. (1998) Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. J Biol Chem. 273(27): 16816-23.
• Kos J, et al. (2009) The role of cathepsin X in cell signaling. Cell Adh Migr. 3(2): 164-6.
• Sevenich L, et al. (2010) Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A. 107(6): 2497-502.