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Anti-CTSV antibody

Cat.#: 141367

Special Price 145.0 USD

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Product Information

  • Product Name
    Anti-CTSV antibody
  • Documents
  • Description
    Rabbit Polyclonal to Human CTSV
  • Tested applications
    WB, ELISA
  • Species reactivity
    Human Cathepsin V / Cathepsin L2 / Preproprotein
  • Alternative names
    Cathepsin L2 antibody; CTSL2 antibody; Cathepsin U antibody; Cathepsin V antibody; CATL2 antibody; CTSU antibody; CTSV antibody; MGC125957 antibody; preproprotein antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    Produced in rabbits immunized with purified, recombinant Human Cathepsin V / Cathepsin L2 / Preproprotein . Cathepsin V / Cathepsin L2 / Preproprotein specific IgG was purified by Human Cathepsin V / Cathepsin L2 / Preproprotein affinity chromatography.
  • Clonality
    Polyclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    WB: 5-20 μg/ml

    ELISA: 0.1-0.2 μg/ml

    This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Human Cathepsin V / Cathepsin L2 / Preproprotein.

  • Validations

    Cathepsin V / Cathepsin L2 / Preproprotein Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

    Cathepsin V / Cathepsin L2 / Preproprotein Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot

  • Background
    Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin. It is a lysosomal cysteine proteinase that may play an important role in corneal physiology. It has about 75% protein sequence identity to murine cathepsin L. The fold of this enzyme is similar to the fold adopted by other members of the papain superfamily of cysteine proteases. Cathepsin V has been recently described as highly homologous to Cathepsin L and exclusively expressed in human thymus and testis. Cathepsin V is the dominant cysteine protease in cortical human thymic epithelial cells, while Cathepsin L and Cathepsin S seem to be restricted to dendritic and macrophage-like cells. Active Cathepsin V in thymic lysosomal preparations was demonstrated by active-site labeling. Recombinant Cathepsin V was capable of converting Ii into CLIP efficiently, suggesting that it is the protease that controls the generation of alphabeta-CLIP complexes in the human thymus. Cathepsin V is the third elastolytic cysteine protease which exhibits the most potent elastase activity yet described among human proteases and that it is present in atherosclerotic plaque specimens. Cathepsin L2 may play a specialized role in the thymus and testis. Expression analysis of cathepsin L2 in human tumors revealed a widespread expression in colorectal and breast carcinomas but not in normal colon or mammary gland or in peritumoral tissues. Cathepsin L2 was also expressed by colorectal and breast cancer cell lines as well as by some tumors of diverse origin, including ovarian and renal carcinomas.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"