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Product Name
Anti-CSEN / calsenilin / KCNIP3 antibody
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Description
Rabbit polyclonal to CSEN / calsenilin / KCNIP3
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Tested applications
ELISA, WB, IP
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Species reactivity
Human CSEN / calsenilin / KCNIP3
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Alternative names
Kv channel interacting protein 3 antibody; calsenilin antibody; KCNIP3 antibody; CSEN antibody; DREAM antibody; KCHIP3 antibody; A-type potassium channel modulatory protein 3 antibody; DRE-antagonist modulator antibody; presenilin-binding protein antibody; EF hand transcription factor antibody; potassium channel interacting protein 3 antibody; Kv channel interacting protein 3 antibody; calsenilin antibody; Kcnip3 antibody; RP23-105O13.3 antibody; 4933407H12Rik antibody; AI413860 antibody; Csen antibody; DREAM antibody; KChIP3 antibody; R74849 antibody; A-type potassium channel modulatory protein 3 antibody; DRE-antagonist modulator antibody; presenilin binding protein antibody; EF hand transcription factor antibody; potassium channel interacting protein 3 antibody; CSEN antibody; DREAM antibody; KCHIP3 antibody; Csen antibody; DREAM antibody; KChIP3 antibody; R74849 antibody; AI413860 antibody; 4933407H12Rik antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human CSEN / calsenilin / KCNIP3 (rh CSEN / calsenilin / KCNIP3; Q9Y2W7-1; Met1-Ile256). CSEN / calsenilin / KCNIP3 specific IgG was purified by Human CSEN / calsenilin / KCNIP3 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-30 μg/ml
ELISA: 0.1-0.2 μg/ml
This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Human CSEN / calsenilin / KCNIP3. The detection limit for Human CSEN / calsenilin / KCNIP3 is approximately < 0.039 ng/well.
IP: 1-4 μg/mg of lysate
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Validations
CSEN / calsenilin / KCNIP3 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
CSEN / calsenilin / KCNIP3 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
Immunochemical staining of human PPIL1 in human epididymis with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
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Background
CSEN, also known as calsenilin and KCNIP3, is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. CSEN also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. CSEN binds to the DRE element of genes including PDYN and FOS.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"