Anti-CHEK1 antibody

Anti-CHEK1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Human CHEK1

WB, ELISA, ICC/IF, IF, IP

Human Chk1

checkpoint kinase 1 antibody; CHEK1 antibody; CHK1 antibody; CHK1 checkpoint homolog antibody; Checkpoint antibody; S. pombe antibody; homolog of antibody; 1 antibody; Chk1-S antibody; cell cycle checkpoint kinase antibody; serine/threonine-protein kinase Chk1 antibody; checkpoint kinase 1 antibody; Chek1 antibody; C85740 antibody; Chk1 antibody; rad27 antibody; CHK1 checkpoint homolog antibody; checkpoint kinase 1 homolog antibody; rad27 homolog antibody; serine/threonine-protein kinase Chk1 antibody; Checkpoint antibody; homolog of antibody; S. pombe antibody; CHK1 antibody; Chk1 antibody; rad27 antibody; C85740 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human Chk1 . Chk1 specific IgG was purified by Human Chk1 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks) are serine/threonine kinases that are involved in the control of the cell cycle. There are two subtypes of chks that have so far been identified, CHK1 / CHEK1 and Chk2. They are essential components to delay cell cycle progression in normal and damaged cells and can act at all three cell cycle checkpoints. Chks are activated by phosphorylation. ATR kinase phosphorylates CHK1 / CHEK1 in response to single strand DNA breaks and ATM kinase phosphorylates Chk2 in response to double strand breaks. Chks phosphorylate Cdc25 phosphatase at Ser216, which leads to Cdc25 sequestration in the cytoplasm. Chks have a role in the physiological stress of hypoxia/reoxygenation. CHK1 / CHEK1 is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. CHK1 / CHEK1 may also negatively regulate cell cycle progression during unperturbed cell cycles.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy