Anti-CES3/Carboxylesterase 3 antibody

Anti-CES3/Carboxylesterase 3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to CES3/Carboxylesterase 3

IHC-P

Human CES3 / Carboxylesterase 3

Carboxylesterase 3 antibody; Carboxylesterase 3 antibody; Ces3 antibody; CES3 antibody; ES31 antibody; FLJ21736 antibody; UNQ869/PRO1887 antibody; TGH antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human CES3 / Carboxylesterase 3 (rh CES3 / Carboxylesterase 3; NP_079198.2; Met1-Glu561).

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Carboxylesterases hydrolyze esters of short-chain fatty acids and have roles in animals ranging from signal transduction to xenobiotic detoxification. In enzymology, a carboxylesterase is an enzyme that catalyzes the chemical reaction: a carboxylic ester + H2O = an alcohol + a carboxylate. Most enzymes from this group belong to the superfamily of hydrolases with alpha/beta protein fold (so called Alpha/beta hydrolase fold), specifically those acting on carboxylic ester bonds. The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a number of proteins with different substrate specificities, such as acetylcholinesterases. Carboxylesterase 3, also known as Liver carboxylesterase 31 homolog and CES3, is a endoplasmic reticulum lumen which belongs to the type-B carboxylesterase/lipase family. CES3 is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. CES3 shows low catalytic efficiency for hydrolysis of CPT-11, a prodrug for camptothecin used in cancer therapeutics. CES3 is expressed in liver, colon and small intestine.

• Augusteyn RC. et al.,1969, Biochim Biophys Acta. 171 (1): 128-37.
• Saito S. et al., 2003, J. Hum. Genet. 48: 249-70.
• Sanghani SP. et al., 2003, Clin Cancer Res. 9: 4983-91.
• Sanghani SP. et al., 2004, Drug Metab Dispos. 32: 505-11.
• Chen R. et al., 2009, J Proteome Res. 8: 651-61.