Anti-CDH8 antibody

Anti-CDH8 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Rat CDH8

ELISA, IHC-P

Rat Cadherin-8 / CDH8

AI851472 antibody; cad8 antibody; Cadherin-8 antibody; Cadherin-8 antibody; Cdh8 antibody; CDH8 antibody; Nbla04261 antibody; cad8 antibody; AI851472 antibody; Nbla04261 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Rat Cadherin-8 / CDH8 . Cadherin-8 / CDH8 specific IgG was purified by Rat Cadherin-8 / CDH8 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Type I cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I  cadherins. Cadherin 8, also known as CDH 8, is a type I I classical cadherin belonging to the cadherin superfamily. As mainly expressed in brain, CDH8 is found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts, and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Human Cadherin 8 is a 799 amino acid single-pass type I  transmembrane protein with a putative 29 aa signal sequence, and a 32 aa propeptide, a 560 aa mature extracellular domain, a 21 aa transmembrane domain and a 157 aa cytoplasmic domain. The human, mouse and rat proteins share approximately 98% homology.