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  • Anti-CD8B / P37 / LEU2 antibody
  • Anti-CD8B / P37 / LEU2 antibody

Anti-CD8B / P37 / LEU2 antibody

Cat.#: 106645

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Product Information

  • Product Name
    Anti-CD8B / P37 / LEU2 antibody
  • Documents
  • Description
    Rabbit monoclonal to CD8B / P37 / LEU2
  • Tested applications
    IHC-P
  • Species reactivity
    Human CD8B / P37 / LEU2
  • Alternative names
    Leu2 antibody; beta polypeptide 1 (p37) antibody; CD8 antigen antibody; Cd8b antibody; CD8B1 antibody; LY3 antibody; Ly-3 antibody; Ly-C antibody; lymphocyte antigen 3 antibody; LYT3 antibody; Lyt-3 antibody; P37 antibody; T lymphocyte surface glycoprotein beta chain antibody; T-cell membrane glycoprotein Ly-3 antibody; T-cell surface glycoprotein CD8 beta chain antibody; T-cell surface glycoprotein CD8 beta chain antibody; T-cell surface glycoprotein Lyt-3 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human CD8B / P37 / LEU2 (rh CD8B / P37 / LEU2; P10966-1; Met1-Pro170).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 1-10 μg/mL

  • Validations

    CD8B / P37 / LEU2 Antibody, Rabbit MAb, Immunohistochemistry

    CD8B / P37 / LEU2 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of human CD8B in human lymph node with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).

    CD8B / P37 / LEU2 Antibody, Rabbit MAb, Immunohistochemistry

    CD8B / P37 / LEU2 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of human CD8B in human spleen with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).

  • Background
    CD8B (CD8b molecule), also known as P37 and LEU2, contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. P37 gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. CD8 is thought to play a role in the process of T-cell mediated killing.
  • References
    • Leahy DJ, et al. (1992) Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Cell. 68(6):1145-62.
    • Gao G, et al. (2000) Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol Today. 21(12):630-6.
    • Devine L, et al. (1999) Orientation of the Ig domains of CD8 alpha beta relative to MHC class I. J Immunol. 162(2):846-51.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"