Anti-CD8a / Lyt2 antibody

Cat.#: 101241

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Product Information

  • Product Name
    Anti-CD8a / Lyt2 antibody
  • Documents
  • Description
    Rabbit monoclonal to CD8a / Lyt2
  • Tested applications
    FCM
  • Species reactivity
    Ferret CD8a / Lyt2
  • Alternative names
    p32 antibody; CD8a antibody; CD8A antibody; Leu2 antibody; BB154331 antibody; CD8 antibody; Ly-2 antibody; Ly-35 antibody; MAL antibody; Ly-B antibody; Lyt-2 antibody; p32 antibody; Ly-2 antibody; Ly-B antibody; Ly-35 antibody; Lyt-2 antibody; BB154331 antibody; CD8 antibody; MAL antibody; Leu2 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Ferret CD8a / Lyt2 (rF CD8a / Lyt2; ABS50091.1; Met1-Glu186) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    CD8a / Lyt2 Antibody (PerCP), Rabbit MAb, Flow cytometric analysis

    CD8a / Lyt2 Antibody (PerCP), Rabbit MAb, Flow cytometric analysis

    Analysis of Ferret CD8A expression on ferret splenocytes. Ferret splenocytes were stained with PerCP-conjugated rabbit anti-Ferret CD8A. The histogram were derived from the gated events based on light scattering characteristics of viable cells.

  • Background
    Human T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I  membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"