Anti-CD69 / CLEC2C antibody

Anti-CD69 / CLEC2C antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to CD69 / CLEC2C

ELISA, WB, IP

Human CD69

5830438K24Rik antibody; AI452015 antibody; AIM antibody; Cd69 antibody; CD69 antibody; CLEC2C antibody; VEA antibody; BL-AC/P26 antibody; EA1 antibody; GP32/28 antibody; MLR-3 antibody; AIM antibody; EA1 antibody; MLR-3 antibody; CLEC2C antibody; GP32/28 antibody; BL-AC/P26 antibody; AIM antibody; VEA antibody; AI452015 antibody; 5830438K24Rik antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human CD69 (rh CD69; NP_001772.1; Ser 62-Lys 199).

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.

• Ziegler SF, et al. (1994) The activation antigen CD69. Stem Cells. 12(5): 456-65.
• Marzio R, et al. (1999) CD69 and regulation of the immune function. Immunopharmacol Immunotoxicol. 21(3): 565-82.
• Lamana A, et al. (2006) The role of CD69 in acute neutrophil-mediated inflammation. Eur J Immunol. 36(10): 2632-8.
• Miki-Hosokawa T, et al. (2009) CD69 controls the pathogenesis of allergic airway inflammation. J Immunol. 183(12): 8203-15.