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Product Name
Anti-CD5L antibody
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Description
Rabbit polyclonal to CD5L
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Tested applications
ELISA, IHC-P
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Species reactivity
Mouse CD5L / Aim
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Alternative names
AI047839 antibody; AIM antibody; API6 antibody; Api6 antibody; Cd5l antibody; CD5L antibody; CT2 antibody; Pdp antibody; PRO229 antibody; SP-ALPHA antibody; Sp-alpha antibody; Spalpha antibody; AAC-11 antibody; 42010 antibody; CT2 antibody; Pdp antibody; Api6 antibody; AAC-11 antibody; AI047839 antibody; Sp-alpha antibody; AIM antibody; API6 antibody; PRO229 antibody; Spalpha antibody; SP-ALPHA antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Mouse CD5L (rh CD5L; NP_033820.2; Met 1-Val 352). CD5L / Aim specific IgG was purified by Mouse CD5L / Aim affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
ELISA:0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CD5L. The detection limit for Mouse CD5L is < 0.039 ng/well.
IHC-P: 0.1-2 μg/ml
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Validations
CD5L / Aim Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Background
CD5L, also known as CD5 antigen-like, is a soluble protein belonging to group B of the scavenger receptor cysteine-rich (SRCR) superfamily and contains three SRCR domains. It is a secreted glycoprotein and expressed by macrophages presentin lymphoid tissues (spleen, lymph node, thymus, and bone marrow). It binds to myelomonocytic and lymphoid cells and may play an important role in the regulation of the innate and adaptive immune systems. CD5L functions as a pattern recognition molecule by binding both lipoteichoic acid (LTA) on Gram positive and lipopolysaccharide (LPS) on Gram negative bacteria. and the SRCR domain 1 of CD5L retains both the LPS and LTA binding activities. In addtion, it is revealed that CD5L seems to play a role as an inhibitor of apoptosis.
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References
- Resnick, D. et al., 1994, Trends Biochem. Sci. 19: 5-8.
- Gebe, J. A. et al., 1997, J. Biol. Chem. 272 (10): 6151–6158.
- Sarrias, M.R. et al., 2004, Crit. Rev. Immunol. 24: 1-37.
- Mukhopadhyay, S. and Gordon, S., 2004, Immunobiology 209: 39-49.
- Sarrias, M. R. et al.,2005, J. Biol. Chem. 280 (42): 35391–35398.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"