Anti-CD46 antibody

Cat.#: 106346

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Product Information

  • Product Name
    Anti-CD46 antibody
  • Documents
  • Description
    Mouse monoclonal to CD46
  • Tested applications
    FCM
  • Species reactivity
    Human CD46
  • Alternative names
    MCP antibody; AHUS2 antibody; CD46 antibody; Cd46 antibody; Mcp antibody; MGC26544 antibody; MIC10 antibody; TLX antibody; TRA2.10 antibody; MCP antibody; TLX antibody; AHUS2 antibody; MIC10 antibody; TRA2.10 antibody; Mcp antibody
  • Immunogen
  • Isotype
    Mouse IgG1
  • Preparation
    This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD46 (rh CD46; EAW93471.1; Met 1-Asp 328) and conjugated with APC under optimum conditions, the unreacted APC was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    CD46 Antibody (APC), Mouse MAb, Flow cytometric analysis

  • Background
    CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"