Anti-CD40/TNFRSF5 antibody

Cat.#: 101348

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Product Information

  • Product Name
    Anti-CD40/TNFRSF5 antibody
  • Documents
  • Description
    Mouse monoclonal to CD40/TNFRSF5
  • Tested applications
    FCM
  • Species reactivity
    Rat CD40 / TNFRSF5
  • Alternative names
    p50 antibody; gp39 antibody; HIGM1 antibody; IGM antibody; IMD3 antibody; T-BAM antibody; TRAP antibody; p50 antibody; Bp50 antibody; CDW40 antibody; TNFRSF5 antibody; IGM antibody; p50 antibody; Bp50 antibody; GP39 antibody; IMD3 antibody; TRAP antibody; HIGM1 antibody; T-BAM antibody; Tnfrsf5 antibody; AI326936 antibody; AI326936 antibody; Bp50 antibody; Bp50 antibody; CD40 antibody; Cd40 antibody; CDW40 antibody; MGC9013 antibody; p50 antibody; RP23-428M13.1 antibody; TNFRSF5 antibody; Tnfrsf5 antibody
  • Immunogen
  • Isotype
    Mouse IgG1
  • Preparation
    This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CD40 / TNFRSF5 (rR CD40 / TNFRSF5; Q4QQW2_RAT; Met1-Arg193) and conjugated with PE under optimum conditions, the unreacted PE was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    CD40 Antibody (PE), Mouse MAb, Flow cytometric analysis

    CD40 Antibody (PE), Mouse MAb, Flow cytometric analysis

    Flow cytometric analysis of Rat CD40 expression on rat splenocytes. SD splenocytes were stained with PE-conjugated anti-Rat CD40 and FITC conjugated anti-Rat CD3 (BD Pharmingen™ Cat. No. 557354). The dot plots were derived from events with the forward and side light-scatter characteristics of intact cells.

  • Background
    CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
  • References
    • van Kooten C, et al. (2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17.
    • Bhushan A, et al. (2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24.
    • Chatzigeorgiou A, et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83.
    • Li R, et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17.
    • Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"