Anti-CD226/DNAM-1 antibody

Cat.#: 105910

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Product Information

  • Product Name
    Anti-CD226/DNAM-1 antibody
  • Documents
  • Description
    Rabbit monoclonal to CD226/DNAM-1
  • Tested applications
    FCM
  • Species reactivity
    Mouse CD226 / DNAM-1
  • Alternative names
    BC051526 antibody; Cd226 antibody; CD226 antibody; DNAM1 antibody; DNAM1 antibody; DNAM-1 antibody; DNAM-1 antibody; PTA1 antibody; Pta1 antibody; TLiSA1 antibody; TLiSA1 antibody; PTA1 antibody; DNAM1 antibody; DNAM-1 antibody; TLiSA1 antibody; Pta1 antibody; DNAM1 antibody; DNAM-1 antibody; TLiSA1 antibody; BC051526 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD226 / DNAM-1 (rM CD226 / DNAM-1; NP_848802.2; Met1-Pro254) and conjugated with APC under optimum conditions, the unreacted APC was removed.
  • Clonality
    Monoclonal
  • Formulation
    Aqueous solution containing 0.5% BSA and 0.09% sodium azide
  • Storage instructions
    This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !
    Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
  • Applications
    FCM
  • Validations

    CD226 / DNAM-1 Antibody (APC), Rabbit MAb, Flow cytometric analysis

    CD226 / DNAM-1 Antibody (APC), Rabbit MAb, Flow cytometric analysis

    Flow cytometric analysis of mouse CD226 expression on mouse splenocytes. BABL/c splenocytes were stained with FITC-conjugated anti-Mouse CD8a and APC-conjugated anti-Mouse CD226. The histogram were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.

  • Background
    The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD226, also known as PTA1 or DNAM-1, is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. High rate of CD226 (Cluster of Differentiation 226) is found on the surface of natural killer cells, platelets, monocytes and a subset of T cells. CD226 have binding sites with CD112 and CD155 and mediate cellular adhesion to other cells containing its ligands.
  • References
    • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
    • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
    • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"