Anti-CD20/MS4A1 antibody

Cat.#: 106402

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Product Information

  • Product Name
    Anti-CD20/MS4A1 antibody
  • Documents
  • Description
    Rabbit monoclonal to CD20/MS4A1
  • Tested applications
    FCM
  • Species reactivity
    Human CD20 / MS4A1
  • Alternative names
    AA960661 antibody; B1 antibody; Bp35 antibody; Cd20 antibody; CD20 antibody; CVID5 antibody; Ms4a2 antibody; S7 antibody; LEU-16 antibody; Ly-44 antibody; MGC3969 antibody; Ms4a1 antibody; MS4A1 antibody; MS4A2 antibody; B1 antibody; S7 antibody; Bp35 antibody; CD20 antibody; CVID5 antibody; MS4A2 antibody; LEU-16 antibody; Cd20 antibody; Ly-44 antibody; Ms4a2 antibody; AA960661 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, Human CD20 Transfected CHO Cells.
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    FCM: 0.5-2 μg/Test

  • Validations

    CD20 / MS4A1 Antibody, Rabbit MAb, Flow cytometric analysis

  • Background
    CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
  • References
    • Tedder TF, et al. (1988) Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci. 85(1): 208-12.
    • Cragg MS, et al. (2005) The biology of CD20 and its potential as a target for mAb therapy. Curr Dir Autoimmun. 8: 140-74..
    • Polyak MJ, et al. (2003) A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 17(7): 1384-9.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"