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Product Name
Anti-CCDC134 antibody
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Description
Rabbit polyclonal to CCDC134
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Tested applications
ELISA, WB, IP
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Species reactivity
Human CCDC134
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Alternative names
2310042L06Rik antibody; AW208859 antibody; dJ821D11.3 antibody; FLJ22349 antibody; MGC21013 antibody; AW208859 antibody; 2310042L06Rik antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human CCDC134 (rh CCDC134; Q9H6E4; Met1-Leu229). CCDC134 specific IgG was purified by Human CCDC134 affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-20 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CCDC134. The detection limit for Human CCDC134 is < 0.039 ng/well.
IP: 1-4 μg/mg of lysate
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Validations
CCDC134 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
CCDC134 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
Human coiled-coil domain containing 134 (CCDC134) is a 229 amino acids secretory protein. Coiled-coil domain is a motif in which alpha-helix are coiled together. It has been found in many types of proteins, including transcription factors, intermediate filaments and certain tRNA synthetases. Many proteins containing such motif CCDC134 are involved in important biological functions. CCDC134 is also considered as a novel human MAPK-regulating protein that can inhibit the MAPK pathway. This protein significantly inhibite Elk1 transcriptional activity. The coiled-coil domain is a ubiquitous protein motif that is often involved in oligomerization.
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References
- Huang J, et al. (2007) CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK. Cellular and Molecular Life Sciences. 65(2): 338-49.
- Kim S, et al. (2011) Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort. Neurology. 76(1): 69-79.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"