Anti-CBFB / CBF-beta antibody

Anti-CBFB / CBF-beta antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to CBFB / CBF-beta

ELISA, WB, IP

Human CBFB / CBF-beta

core-binding factor antibody; beta subunit antibody; CBFB antibody; PEBP2B antibody; CBF-beta antibody; PEA2-beta antibody; PEBP2-beta antibody; SL3-3 enhancer factor 1 beta subunit antibody; SL3-3 enhancer factor 1 subunit beta antibody; SL3/AKV core-binding factor beta subunit antibody; core-binding factor subunit beta antibody; polyomavirus enhancer binding protein 2 antibody; beta subunit antibody; polyomavirus enhancer-binding protein 2 beta subunit antibody; core binding factor beta antibody; Cbfb antibody; AI893578 antibody; PEA2 antibody; PEBP2b antibody; Pebp2 antibody; Pebpb2 antibody; CBF-beta antibody; PEA2-beta antibody; PEBP2-beta antibody; SL3-3 enhancer factor 1 subunit beta antibody; SL3/AKV core-binding factor beta subunit antibody; core-binding factor subunit beta antibody; polyomavirus enhancer-binding protein 2 beta subunit antibody; PEA2 antibody; Pebp2 antibody; PEBP2b antibody; Pebpb2 antibody; AI893578 antibody; PEBP2B antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human CBFB / CBF-beta (rh CBFB / CBF-beta; Q13951-1; Met1-Pro182). CBFB / CBF-beta specific IgG was purified by Human CBFB / CBF-beta affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). CBFB is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for CBFB gene.  Mutations in CBFB are implicated in cases of breast cancer.

• Hart SM. et al., 2003, Haematologica. 87(12): 1307-23.
• Liu P. et al., 1995, Cold Spring Harb Symp Quant Biol. 59: 547-53.
• Liu P. et al., 1993, Science. 261 (5124): 1041-4.