Anti-Caveolin-1 Rabbit antibody

Cat.#: 167041

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Product Information

  • Product Name
    Anti-Caveolin-1 Rabbit antibody
  • Documents
  • Description
    Caveolin-1 Rabbit polyclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF
  • Species reactivity
    Human
  • Alternative names
    CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human Caveolin-1
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000-1/5000

    IHC: 1/20

    ICC/IF: 1/20

  • Validations

    Western blot detection of Caveolin-1 in Hela cell lysates using Caveolin-1 Rabbit pAb(1:1000 diluted).Predicted band size:20kDa.Observed band size:20kDa.

    Western blot detection of Caveolin-1 in Hela cell lysates using Caveolin-1 Rabbit pAb(1:1000 diluted).Predicted band size:20kDa.Observed band size:20kDa.

    Immunohistochemistry of Caveolin-1 in paraffin-embedded Human breast cancer tissue using Caveolin-1 Rabbit pAb at dilution 1/20

    Immunohistochemistry of Caveolin-1 in paraffin-embedded Human breast cancer tissue using Caveolin-1 Rabbit pAb at dilution 1/20

  • Background
    Swiss-Prot Acc.Q03135.May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity . Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"