Anti-Cathepsin D Rabbit antibody

Cat.#: 167391

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Product Information

  • Product Name
    Anti-Cathepsin D Rabbit antibody
  • Documents
  • Description
    Cathepsin D Rabbit polyclonal antibody
  • Tested applications
    WB, IHC-P, ICC/IF, IP, FC
  • Species reactivity
    Human, Mouse, Rat
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthesized peptide derived from human Cathepsin D
  • Clonality
    Polyclonal
  • Formulation
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500-1/2000

    IHC: 1/50-1/200

    ICC/IF: 1/50-1/200

    IP: 1/50

    FC: 1/20

  • Validations

    Immunohistochemical analysis of paraffin-embedded human ovarian cancer, using Cathepsin D Antibody.

    Immunohistochemical analysis of paraffin-embedded human ovarian cancer, using Cathepsin D Antibody.

    Western blot analysis of Cathepsin D expression in (1)MCF-7 cell lysate;(2)SKBR-3 cell lysate.

    Western blot analysis of Cathepsin D expression in (1)MCF-7 cell lysate;(2)SKBR-3 cell lysate.

  • Background
    Swiss-Prot Acc.P07339.This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"