Anti-Carboxypeptidase B2/CPB2 antibody

Anti-Carboxypeptidase B2/CPB2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to Carboxypeptidase B2/CPB2

IHC-P

Human Carboxypeptidase B2 / CPB2

1110032P04Rik antibody; 4930405E17Rik antibody; AI255929 antibody; Carboxypeptidase B2 antibody; Carboxypeptidase B2 antibody; Cpb2 antibody; CPB2 antibody; CPR antibody; Cpu antibody; CPU antibody; MGC107573 antibody; PCPB antibody; TAFI antibody; TAFI antibody; PCPB antibody; CPU antibody; TAFI antibody; CPR antibody; Cpu antibody; TAFI antibody; AI255929 antibody; 1110032P04Rik antibody; 4930405E17Rik antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human Carboxypeptidase B2 / CPB2 (rh Carboxypeptidase B2 / CPB2; NP_001863.2; Met1-Val423). Carboxypeptidase B2 / CPB2 specific IgG was purified by Human Carboxypeptidase B2 / CPB2 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by thrombin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin / thrombomodulin complex. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. CPB2 exhibits carboxypeptidase activity and activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

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