Anti-Carbonic Anhydrase VB antibody

Anti-Carbonic Anhydrase VB antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to Carbonic Anhydrase VB

IHC-P

Human Carbonic Anhydrase VB / CA5B
Has cross-reactivity in ELISA with Human CA2; Human CA3; Human CA5A
No cross-reactivity in ELISA with Human CA8; Human CA4

7330410H16Rik antibody; Ca5b antibody; CA5B antibody; Car5b antibody; carbonate dehydratase VB antibody; carbonate dehydratase VB antibody; carbonic anhydrase 5B antibody; carbonic anhydrase 5B antibody; Carbonic Anhydrase VB antibody; Carbonic Anhydrase VB antibody; CarVb antibody; CAVB antibody; CA-VB antibody; CA-VB antibody; D730005F19Rik antibody; MGC39962 antibody; RP23-391L6.3 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human Carbonic Anhydrase VB / CA5B (rh Carbonic Anhydrase VB / CA5B; Q9Y2D0; Cys34-Pro317).

Monoclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Carbonic anhydrase 5B, also known as carbonate dehydratase VB, carbonic anhydrase VB, CA-VB and CA5B, is a member of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart, pancreas, kidney, placenta, lung, and skeletal muscle. It is not expressed in liver. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CAs show extensive diversity in tissue distribution and in their subcellular localization. CA5B / CA-VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA5A / CA-VA. CA5B / CA-VB has a wider tissue distribution than CA5A / CA-VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. CA5A / CA-VA is activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. It is inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt). CA5B / CA-VB is inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).

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