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Anti-c-Fos (7D6) Mouse antibody

Cat.#: 168238

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Product Information

  • Product Name
    Anti-c-Fos (7D6) Mouse antibody
  • Documents
  • Description
    c-Fos (7D6) Mouse monoclonal antibody
  • Tested applications
    WB
  • Species reactivity
    Human, Rat, Monkey
  • Alternative names
    Activator protein 1;AP 1;Cellular oncogene c fos;Cellular oncogene fos;FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS);FBJ murine osteosarcoma viral v fos oncogene homolog;FBJ Osteosarcoma Virus;FOS;FOS protein;FOS_HUMAN;G0 G1 switch antibody
  • Isotype
    Mouse IgG1
  • Preparation
    Antigen: Purified recombinant human FOS protein fragments expressed in E.coli.
  • Clonality
    Monoclonal
  • Formulation
    Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
  • Storage instructions
    Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Applications

    WB: 1/500;Other 1/500

  • Validations

    Western blot detection of c-Fos in HCT116,COS7 and C6 cell lysates using c-Fos mouse mAb (1:500 diluted).Predicted band size:62KDa.Observed band size:62KDa.

    Western blot detection of c-Fos in HCT116,COS7 and C6 cell lysates using c-Fos mouse mAb (1:500 diluted).Predicted band size:62KDa.Observed band size:62KDa.

    Western blot detection of c-Fos in Hela(TSA treated ) and Hela cell lysates using c-Fos mouse mAb (1:500 diluted).Predicted band size:62KDa.Observed band size:62KDa.

    Western blot detection of c-Fos in Hela(TSA treated ) and Hela cell lysates using c-Fos mouse mAb (1:500 diluted).Predicted band size:62KDa.Observed band size:62KDa.

    Western blot analysis of extracts from Hela cells,untreated,50 u03bcM TSA-treated or 50 u03bcM TPA-treated for 24h,using C-FOS antibody (1:500 diluted)(upper) or GAPDH antibody (1:10000 diluted) (lower).

    Western blot analysis of extracts from Hela cells,untreated,50 u03bcM TSA-treated or 50 u03bcM TPA-treated for 24h,using C-FOS antibody (1:500 diluted)(upper) or GAPDH antibody (1:10000 diluted) (lower).

  • Background
    Swiss-Prot Acc.P01100.Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor.In the heterodimer,FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites.On TGF-beta activation,forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling.Has a critical function in regulating the development of cells destined to form and maintain the skeleton.It is thought to have an important role in signal transduction,cell proliferation and differentiation.In growing cells,activates phospholipid synthesis,possibly by activating CDS1 and PI4K2A.This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"