Anti-BLyS/TNFSF13B antibody

Anti-BLyS/TNFSF13B antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to BLyS/TNFSF13B

ELISA, WB, IP

Human BAFF / TNFSF13B

BAFF antibody; BAFF antibody; BlyS antibody; BLYS antibody; CD257 antibody; D8Ertd387e antibody; DTL antibody; MGC124060 antibody; MGC124061 antibody; TALL1 antibody; TALL1 antibody; TALL-1 antibody; TALL-1 antibody; THANK antibody; THANK antibody; Tnfsf13b antibody; TNFSF13B antibody; DTL antibody; BAFF antibody; BLYS antibody; CD257 antibody; TALL1 antibody; THANK antibody; ZTNF4 antibody; TALL-1 antibody; TNFSF20 antibody; BAFF antibody; BLyS antibody; TALL1 antibody; THANK antibody; zTNF4 antibody; TALL-1 antibody; TNFSF20 antibody; D8Ertd387e antibody; TNFSF20 antibody; TNFSF20 antibody; zTNF4 antibody; ZTNF4 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human BAFF / TNFSF13B (rh BAFF / TNFSF13B; Q9Y275-1; Ala134-Leu285). BAFF / TNFSF13B specific IgG was purified by Human BAFF / TNFSF13B affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). These receptors is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. Thus, it acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. Overexpression of BLyS in mice can lead to clinical and serological features of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). BLyS as an attractive therapeutic target in human rheumatic diseases. The ability of BLyS to regulate both the size and repertoire of the peripheral B cell compartment raises the possibility that BLyS and antagonists thereof may form the basis of a therapeutic trichotomy. As an agonist, BLyS protein may enhance humoral immunity in congenital or acquired immunodeficiencies such as those resulting from viral infection or cancer therapy.

• Nardelli B, et al. (2002) B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases. Leuk Lymphoma. 43(7): 1367-73.
• Stohl W. (2006) Therapeutic targeting of B lymphocyte stimulator (BLyS) in the rheumatic diseases. Endocr Metab Immune Disord Drug Targets. 6(4): 51-8.
• Cancro MP, et al. (2009) The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus. J Clin Invest. 119(5): 1066-73.