Anti-BLNK/Ly-57/SLP-65 antibody

Anti-BLNK/Ly-57/SLP-65 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to BLNK/Ly-57/SLP-65

ELISA, WB, IHC-P

Human BLNK / Ly-57 / SLP-65

BASH antibody; BASH antibody; Bca antibody; Blnk antibody; BLNK antibody; BLNK-S antibody; Ly57 antibody; LY57 antibody; Ly-57 antibody; Ly-57 antibody; Lyw-57 antibody; MGC111051 antibody; SLP65 antibody; SLP-65 antibody; SLP-65 antibody; Bca antibody; BASH antibody; Ly57 antibody; Ly-57 antibody; Lyw-57 antibody; SLP-65 antibody; bca antibody; AGM4 antibody; BASH antibody; LY57 antibody; SLP65 antibody; BLNK-S antibody; SLP-65 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human BLNK / Ly-57 / SLP-65 (rh BLNK / Ly-57 / SLP-65; P08195-1; Met 1-Ser 456). BLNK / Ly-57 / SLP-65 specific IgG was purified by Human BLNK / Ly-57 / SLP-65 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65 and BLNK, is a cytoplasm and cell membrane protein which contains one SH2 domain. BLNK is expressed in B-cell lineage and fibroblast cell lines. Highest levels of expression is in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon. BLNK functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. BLNK plays a role in the activation of ERK / EPHB2, MAP kinase p38 and JNK. BLNK modulates AP1 activation. It is important for the activation of NF-kappa-B and NFAT. BLNK plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. BLNK may be required for the RAC1-JNK pathway. It plays a critical role in orchestrating the pro-B cell to pre-B cell transition. BLNK also plays an important role in BCR-induced B-cell apoptosis. Defects in BLNK are the cause of agammaglobulinemia type 4 (AGM4) which is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.

• Fu C., et al., 1998, Immunity 9:93-103.
• Minegishi Y., et al., 1999, Science 286:1954-1957.
• Chiu C.W., et al., 2002, EMBO J. 21:6461-6472.
• Taguchi T., et al., 2004, Immunology 112:575-582.