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Product Name
Anti-BIN1 Rabbit antibody
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Description
BIN1 Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC
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Species reactivity
Human, Mouse, Rat
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Alternative names
CNM2; AMPH2; AMPHL; SH3P9 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human BIN1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/20
ICC/IF: 1/20
FC: 1/20
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Validations
Immunohistochemistry of BIN1 in paraffin-embedded Human tonsil using BIN1 Rabbit pAb at dilution 1/20
Western blot detection of BIN1 in Rat Brain lysates using BIN1 Rabbit pAb(1:1000 diluted).Predicted band size:65kDa.Observed band size:45-80kDa.
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Background
Swiss-Prot Acc.O00499.Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis . Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates . May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"