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Product Name
Anti-BAP1 Rabbit antibody
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Description
BAP1 Rabbit monoclonal antibody
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Tested applications
WB, FC
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Species reactivity
Human
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human BAP1
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Clonality
Monoclonal
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Formulation
50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/1000
FC: 1/20
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Validations
Western blot detection of BAP1 in Hela,A549,HL-60,U2OS cell lysates using BAP1 Rabbit mAb(1:1000 diluted).Predicted band size:80kDa.Observed band size:95kDa.
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Background
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"