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Product Name
Anti-Bad Rabbit antibody
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Description
Bad Rabbit polyclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, FC, IP
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Species reactivity
Human, Mouse, Rat
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Alternative names
BBC2; BCL2L8 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Bad
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
IHC: 1/50
ICC/IF: 1/50
FC: 1/20
IP: 1/20
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Validations
Western blot detection of Bad in Rat Brain,C6,3T3,Hela cell lysates using Bad Rabbit pAb(1:1000 diluted).Predicted band size:18kDa.Observed band size:23kDa.
Immunohistochemistry of Bad in paraffin-embedded Human breast cancer tissue using Bad Rabbit pAb at dilution 1/50
Immunocytochemistry of Bad(green) in Hela cells using Bad Rabbit pAb at dilution 1/50, and DAPI(blue)
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Background
Swiss-Prot Acc.Q92934.Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 . Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"