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Product Name
Anti-Atrx antibody
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Description
Mouse monoclonal antibody to Atrx
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Tested applications
ICC, IHC-P
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Species reactivity
Mouse
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Alternative names
X antibody; Rad antibody; XH2 antibody; Xnp antibody; ATR2 antibody; Hp1b antibody; MRXS3 antibody; Rad54 antibody; HP1-BP antibody; Hp1bp2 antibody; RAD54L antibody; ZNF-HX antibody; Hp1bp38 antibody; AI447451 antibody; HP1-BP38 antibody; DXHXS6677 antibody; DXHXS6677E antibody; 4833408C14Rik antibody
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Isotype
IgG1
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Preparation
This antigen of this antibody was this antibody is produced by immunizing mice with recombinant protein of mouse atrx.
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Clonality
Monoclonal
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Formulation
Liquid, 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
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Applications
ICC: 1:200
IHC-P: 1:200
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Validations
Fig1: ICC staining ATRX in mouse embryonic cells D3 (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Fig2: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti- ATRX mouse monoclonal antibody.
- Background
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References
- ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner. Law M.J., Lower K.M., Voon H.P., Hughes J.R., Garrick D., Viprakasit V., Mitson M., De Gobbi M., Marra M., Morris A., Abbott A., Wilder S.P., Taylor S., Santos G.M., Cross J., Ayyub H., Jones S., Ragoussis J.Gibbons R.J. Cell 143:367-378(2010)
- ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain. Kernohan K.D., Jiang Y., Tremblay D.C., Bonvissuto A.C., Eubanks J.H., Mann M.R., Berube N.G. Dev. Cell 18:191-202(2010)
- Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin. Eustermann S., Yang J.C., Law M.J., Amos R., Chapman L.M., Jelinska C., Garrick D., Clynes D., Gibbons R.J., Rhodes D., Higgs D.R., Neuhaus D. Nat. Struct. Mol. Biol. 18:777-782(2011)
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