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Product Name
Anti-ATG16L1 Rabbit antibody
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Description
ATG16L1 Rabbit polyclonal antibody
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Tested applications
WB
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Species reactivity
Human, Mouse, Rat
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Alternative names
IBD10; WDR30; APG16L; ATG16A; ATG16L antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human ATG16L1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/2000
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Validations
Western blot detection of ATG16L1 in 3T3 cell lysates using ATG16L1 Rabbit pAb(1:1000 diluted).Predicted band size:68kDa.Observed band size:68kDa.
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Background
Swiss-Prot Acc.Q676U5.Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"