Anti-Arylsulfatase A / ARSA antibody

Anti-Arylsulfatase A / ARSA antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to Arylsulfatase A / ARSA

ELISA, WB, IP

Mouse Arylsulfatase-A / ARSA

Arsa antibody; ARSA antibody; Arylsulfatase A antibody; Arylsulfatase A antibody; As2 antibody; As-2 antibody; ASA antibody; AS-A antibody; AW212749 antibody; C230037L18Rik antibody; MLD antibody; TISP73 antibody; MLD antibody; ASA antibody; As2 antibody; AS-A antibody; As-2 antibody; TISP73 antibody; AW212749 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Mouse ARSA (rM ARSA; NP_033843.2; Met 1-Ser 506). ARSA specific IgG was purified by Mouse ARSA affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS with 5% trehalose

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Arylsulfatase A (ARSA) is synthesized as a 52KDa lysosomal enzyme. It is a member of the sulfatase family that is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet. Arylsulfatase A is activated by a required co- or posttranslational modification with the oxidation of cysteine to formylglycine. Metachromatic leukodystrophy (MLD) is a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms caused by the deficiency of Arylsulfatase A. Deficiency of this enzyme is also found in apparently healthy individuals, a condition for which the term pseudodeficiency is introduced. ARSA forms dimers after receiving three N-linked oligosaccharides in the endoplasmic reticulum, and then the dimers are transported to the Golgi where they receive mannose 6-phosphate recognition markers. And thus, ARSA is transported and delivered to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. It has been shown that within the lysosomes, the ARSA dimers can oligomerize to an octamer in a pH-dependent manner. The ARSA deficiency leads to metachromatic leucodystrophy (MLD), a lysosomal storage disorder associated with severe and progressive demyelination in he central and peripheral nervous system. Additionally, the serum level of arylsulfatase A might be helpful in diagnosis of lung and central nervous system cancer.

• Laidler PM. (1991) Arylsulfatase A--physico-chemical properties and the use of enzyme radioimmunoassay in medical diagnosis Folia Med Cracov. 32(3-4): 149-68.
• Jean S, et al. (2006) Ethanol decreases rat hepatic arylsulfatase A activity levels. Alcohol Clin Exp Res. 30(11): 1950-5.