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Product Name
Anti-Aryl hydrocarbon Receptor Rabbit antibody
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Description
Aryl hydrocarbon Receptor Rabbit polyclonal antibody
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Tested applications
WB, ICC/IF
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Species reactivity
Human
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Alternative names
bHLHe76 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human Aryl hydrocarbon Receptor
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
ICC/IF: 1/20
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Validations
Immunocytochemistry of Aryl hydrocarbon Receptor(green) in Hela cells using Aryl hydrocarbon Receptor Rabbit pAb at dilution 1/50, and DAPI(blue)
Western blot detection of Aryl hydrocarbon Receptor in Hela cell lysates using Aryl hydrocarbon Receptor Rabbit pAb(1:1000 diluted).Predicted band size:96kDa.Observed band size:100kDa.
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Background
Swiss-Prot Acc.P35869.Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"