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Product Name
Anti-APPBP1 Rabbit antibody
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Description
APPBP1 Rabbit polyclonal antibody
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Tested applications
WB, FC, IP
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Species reactivity
Human, Rat
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Alternative names
HPP1; ula-1; APPBP1; A-116A10.1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human APPBP1
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000-1/2000
FC: 1/20
IP: 1/20
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Validations
Western blot detection of APPBP1 in SKOV-3 cell lysates using APPBP1 Rabbit pAb(1:1000 diluted).Predicted band size:60KDa.Observed band size:60KDa.
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Background
Swiss-Prot Acc.Q13564.Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"